Effects of 12-0-tetradecanoylphorbol-13-acetate (TPA) on liver metabolism
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چکیده
منابع مشابه
12-O-tetradecanoylphorbol-13-acetate (TPA) increases murine intestinal crypt stem cell survival following radiation injury
Radiation enteropathy is a common complication in cancer patients following radiation therapy. Thus, there is a need for agents that can protect the intestinal epithelium against radiation. 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce differentiation and/or apoptosis in multiple cell lines and primary cells. In the current report, we studied the function of TPA in radiati...
متن کامل12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT
TPA stimulates carcinogenesis in various types of cancers. However, we found that TPA inhibits transformative phenotypes in liver cancer cells via the translocation of YAP from the nucleus, where it functions as a transcriptional co-factor, to the cytoplasm. Such effects led to a separation of YAP from its dependent transcription factors. The inhibitory effects of TPA on YAP were AMOT dependent...
متن کاملEffects of 12-O-tetradecanoylphorbol-13-acetate on the differentiation of avian melanocytes.
12-O-Tetradecanoylphorbol-13-acetate (TPA) has been reported to inhibit and/or delay the terminal differentiation of a variety of cell types. More recently, TPA has been reported to enhance melanogenesis in cultured human melanoma cells. This study focuses on the effect of TPA on the differentiation of normal avian melanocytes. TPA blocked melanogenesis in normal replicating presumptive melanob...
متن کاملEffects of 12-O-Tetradecanoylphorbol-13-acetate on the Differentiation of Avian Melanocytes1
12-O-Tetradecanoylphorbol-13-acetate (TPA) has been re ported to inhibit and/or delay the terminal differentiation of a variety of cell types. More recently, TPA has been reported to enhance melanogenesis in cultured human melanoma cells. This study focuses on the effect of TPA on the differentiation of normal avian melanocytes. TPA blocked melanogenesis in normal replicating presumptive melano...
متن کاملDifferentiation of human leukemias in response to 12-0-tetradecanoylphorbol-13-acetate in vitro.
Leukemic cells from patients with acute myeloid leukemia underwent morphological, functional, and histochemical changes within 24-48 hr after treatment with 1.6 x 10-18 M 12-0-tetradecanoylphorbol-13-acetate (TPA). The changes included adhesion to the plastic substrate, a 4-6-fold increase in the number of phagocytic cells, and an increase in the number of alpha-naphthyl-acetate esterase (alpha...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1986
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)59074-6